Umuthi 'Torcida ": yokusetshenziswa, incazelo, ukwakheka kanye nokubuyekeza. "Torcida": yokusetshenziswa (amaphilisi)

Eminyakeni yamuva nje, odokotela yesimanje ngokwethukela waqala ukuba linqume ukuba iziguli zabo lokhu izidakamizwa ngokuthi "Torcida". Yokusetshenziswa kuhlanganisa kuphela idatha eziyisisekelo ezidingekayo ukuze umuntu evamile ukuthatha izidakamizwa, kodwa eziningi ngaphambi kokuthenga noma ngemva yokufuna uzama ukufunda ulwazi oluningi mayelana leli thuluzi.

pharmacodynamics

Lesi sidakamizwa kuyinto saluretic. Kuyinto unesibopho impendulo okusithiyayo reabsorption kwezinso sodium kanye chloride ion, okuyinto zitholakala ekuntweleni ingxenye iluphu Henle sika, okuboniswe emuthini "torsida" imfundo manual.

Pharmacokinetics

Le ndoda, ngemva kokuphathwa emthanjeni izimali ngokushesha iqala ukubonisa umphumela isisu. Kulokhu umphumela nokukhawulela zomuthi eba ngaphakathi 3 amahora kuqala futhi kamuva agcinwe kuze amahora 12. On ngemuva lolu hlelo lokusebenza kusho diuresis encike ngqo kwi umthamo, okuyilona elisebenzayo futhi wabonisa ukuthi lesi sidakamizwa "torsida" imfundo manual.

Torasemide degree of sesibopho ukuthobisa plasma amaprotheni eliphezulu njengoba 99%, okuyinto umphumela omuhle kakhulu, kuyilapho metabolites M1, M3 kanye M5 axhunyaniswa ngokulandelana at 86,95 futhi 97%. Ubuningi kungenzeka ukuqedwa isigamu-ukuphila torasemide futhi metabolites yayo ezahlukene enempilo wafunda, ezisukela emithathu kuya kwemine amahora, okuyinto kwahlonzwa ngokuhamba zokwelapha.

imvume Ubude efana imayelana 40 ml / imiz., Nakuba kwezinso imvume izinga imayelana 10 ml / imiz. Metabolite M5 ukhiqiza akunamthelela isisu, kuyilapho nhlanganisela metabolites M3 kanye M1 zaba cishe 10% isenzo pharmacodynamic bafakela umzimba womuntu.

Izici zomuthi kubantu yizifo ngezifo

Uma isiguli wembula ukwehluleka kwezinso, ke akuphazamisi kusebenta jikelele imvume futhi isigamu-ukuphila torasemide, kube kwandziswa isikhathi metabolites M5 kanye M3. Ngesikhathi esifanayo agcinwe ngokuphelele kokuqala izici pharmacodynamic, kodwa isikhathi kwezidakamizwa isinyathelo ukwehluleka kwezinso futhi akunamthelela, kungakhathaliseki kobukhulu isifo.

Ngo yalezo ziguli ukuzwa isibindi ukungasebenzi, noma ukumelwa inhliziyo, izikhathi eziningana anda metabolite excretion of torasemide futhi M5, okuboniswe emuthini "Torcida" imfundo manual.

Inani ketshezi okukhipha umchamo cishe ngokuphelele oluhambisana lemali ukuthi ebonwe amavolontiya aphilile, ngokuqondene yena ngokwakhe torasemide futhi metabolites yayo akusho cumulate.

ubufakazi

Ezimweni eziningi, izidakamizwa esebenzayo kunenzuzo enikezwa odokotela ekwelapheni exudates ahlukahlukene noma edema kokuvela ngokuqondene yokumelwa yinhliziyo. Kufanele kuqashelwe ukuthi lesi sidakamizwa "Torcida" yokusetshenziswa (amaphilisi) lubonisa ukuthi ezinqunyiwe, uma kunesidingo, therapy ejwayelekile.

Izimo

Kukhona ezinye izimo lapho ukusetshenziswa kwalesi izidakamizwa is a non-Kunconywa noma kungavunyelwa ngokuphelele. Kuchaza sinamathele izidakamizwa "Torcida" yokusetshenziswa (amaphilisi - kubhekwa ifomu), ukunikeza ezinye eziyisisekelo:

• khona iziguli lwemithambo hypotension;
• ukuzwela ngokweqile ezintweni ezahlukene asizayo noma asebenzayo, kanye nezinye sulfonylureas;
• hhayi Kunconywa iziguli nokwehluleka ukusebenza kwezinso nge anuria;
• anemisebenzi ezinzima isibindi;
• zonke izinhlobo ukwephula amanzi-electrolyte uhlelo ibhalansi;
• sifo;
• uma isiguli uhlushwa iziyaluyalu ezinzima ohlelweni urinary;
• zonke izinhlobo ukwephulwa conductive ophakemeyo simiso inhliziyo;
• izinguquko sokugembula esithombeni jikelele legazi acid-base isimo umuntu;
• yokuphazamiseka ukusebenza izinso kubangelwa izilonda nephrotoxic izinto ezihlukahlukene.

Phakathi kwezinye izinto, it is hhayi Kunconywa ukusebenzisa leli thuluzi ngoba abesifazane abahlala esikhathini okukhulelwa noma lactation.

Indlela esetshenziswa?

Uma usebenzisa i-ewuketshezi, umenzeli kufanele sinikezwe kuphela ngemithambo yegazi futhi kancane, njengoba kufakazelwa izidakamizwa "Torcida" imfundo manual. Intengo ithuluzi (ruble angamakhulu amahlanu) kuyinto abantu ngokulunga kufinyeleleke futhi ngenxa yalokho abaningi kungabi izinkinga ukuze ukuhambisana kahle izimpawu ukusetshenziswa kwaso.

umthamo owodwa lokuqala mayelana 10 mg ngelanga, isb 2 ml le nokulungiselela. Uma kukhona kancane inzuzo yomtholampilo, umthamo ke zingandiswa kabili. Kodwa uma akunakwenzeka ukufeza kahle efanele, khona-ke umthamo kungenziwa lenyuke ngisho kabili, kodwa ukwelashwa kufanele kudonse esiphezulu lwezinyawo lwezinsuku ezintathu.

Acute edema yamaphaphu

Uma usebenzisa lokhu ejenti uphulukisa acute edema yamaphaphu, umthamo starting 20 mg, nimbize kuye isithombe Imininingwane emitholampilo lokhu umthamo iqondiswa zonke ingxenye yehora. Kufanele kuqashelwe ukuthi impatho enjalo umthamo Imininingwane kumele singeqi angu 100 ngosuku torsemide.

Ukuze ukwelashwa eyalandela Kunconywa njengendlela isikhathi esingaphezu kwesonto, futhi okuyinyanga yokugujwa emuthini "Torcida" yokusetshenziswa ingasetshenziswa ukushintshela ekuphathweni ngomlomo njengoba emthanjeni akufanele isetshenziswe. Inani (izibuyekezo siliqinisekise) njengendlela tablet futhi into ewuketshezi utholwa abaningi, ngakho uze uwaqede yokwelashwa ayivamile ukubangela kobunzima. Kunoma ikuphi, esiphezulu kungenzeka umthamo wansuku zonke kumele singeqi 100 mg.

ukuhluleka hepatic

Endabeni izindlela kweziguli ukungakhuli hepatic okudingeka ulisebenzise ngokuqapha esiphezulu, njengoba kulokhu kukhona ingozi ukwanda kwamagesi torasemide ku yokwakheka oketshezini olungenambala lwegazi. Kuyaqapheleka ngokwehlukene lesi sidakamizwa "torsida" (10 mg) e bhukwana imfundo (ithebhulethi noma uketshezi ifomu ukulungiselela - engabalulekile).

Asebekhulile

Ngoba impatho salezi ziguli alinikezi indlela ngamunye ukukhetha umthamo. Kuyaphawuleka yokuthi akukho izifundo ezinkulu zokwelapha phezu Ukuqhathanisa nezinqubo yokuphathwa intsha kanye nabantu abadala akuyona kwenziwe, futhi ngenxa yalokho kungcono ukuba uthintane phambili udokotela zangaphambi oqeqeshiwe.

Isixazululo for umjovo kufanele kancane iqondiswa ngemithambo yegazi, futhi ngaleyo ndlela kuba ngabe yikuphi hhayi intraarterially ogcizelela ngokwehlukene lesi sidakamizwa "torsida" yokusetshenziswa (ampoules).

side effects

Kuyaphawuleka iqiniso lokuthi ukusabela ezingezinhle kungathinta Yiqiniso kwezitho ahlukahlukene, ngakho esimweni ngasinye ezocatshangelwa eceleni:

• Isimiso senhliziyo nemithambo yegazi. Kulokhu, kanti ukuthatha izidakamizwa kungaba iziyaluyalu samanje ezahlukene ukulinganisela uketshezi electrolyte, kuyilapho kwezinye izimo ezingavamile futhi anda alkalosis umzimba. Ngaphezu kwalokho, ezigabeni ezithile iziguli ziba ukudideka, thrombosis, hypotension, ischemia palsy futhi inhliziyo, acute isilethikusebenza, angina futhi nakwisyncope.
• Isimiso sezinzwa. Ezimweni ezingavamile, ikakhulukazi ngendlela efanele usaqala ukwelashwa, kungase kube ubuhlungu bekhanda, ukukhathala ngokweqile, isiyezi, futhi imisipha amajaqamba.
• Isimiso sokugaya ukudla bungene. Ezimweni ezingavamile, kungase kube iziyaluyalu samanje wokugaya ukudla e inqubo nendlela ukusebenzisa imithi "Torcida". Yokusetshenziswa kuphawula okulandelayo side effects: isicanucanu, ukungabi esesuthi, ukuhlanza, ukukhishwa isisu, ubuhlungu esiswini. Kungase kube khona amazinga aphezulu ngokweqile enzyme hepatic.
• Uhlelo urinary. Iziguli ukuzwa thuthuva ezahlukene ukuchama uhlelo, kukhona ukuchama sasivumela olunzulu, okungase luholele alibale futhi elula engahlula esinyeni. Ezimweni ezingavamile, kungase ukwethula isilinganiso amahlombe creatinine kanye urea egazini.
• Umzimba. Ezimweni ezingavamile, iziguli eqoshiwe ukwanda amazinga isiyonke uric acid, lipids kanye glucose egazini.
• uhlelo igazi. Ezimweni ezingandile kakhulu, inciphise inani ingqikithi erythrocyte, leukocyte nama-platelet.
• Amasosha omzimba. Ezimweni ezingavamile, ukuqubuka, photosensitivity, pruritus. Ngu izidakamizwa "torsida" (imijovo) yokusetshenziswa okubonisa ukuthi kwezinye izimo ngemva kokuphathwa emthanjeni bangase baqale ukuthuthukisa acute hypersensitivity ukusabela, lapho isiguli usizo okusheshayo Ubuningi bamahora kumele inikezwe. Ezimweni ezithile, ungase uzizwe isikhumba ukusabela kabi komzimba.

Uma sikhuluma umthelela zincane, le paraesthesia ezingavamile, nomlomo owomile. Ngaphezu kwalokho, ukunakekelwa okukhethekile kufanele ikhokhwe yokuthi ezimweni ezingajwayelekile kakhulu abantu kukhona ezinye ongaboni kanye ukuvela tinnitus, noma ukulahlekelwa ephelele ukuzwa.

ukweqisa izidakamizwa

izimpawu ejwayelekile ezimeni izidakamizwa ukweqisa izidakamizwa ngesikhathi engaziwa okwamanje. Manual ubonisa ukuthi uma kwenzeka ngokweqile kungase kube khona diuresis ngokwanele, futhi ingozi ukulahleka okunzima electrolyte namanzi, ukozela kanye amential syndrome. Phakathi kwezinye izinto, ukweqisa izidakamizwa kwenzeka ukwehluleka senhliziyo nemithambo yegazi, hypotension neziyaluyalu ezahlukene ipheshana wokugaya ukudla.

Indlela esiphatha ngayo?

Noma yimuphi yokuvimbela ethize okwamanje engakaze kwembulwe. Ezimweni eziningi, izimpawu eziwumphumela ukudakwa, zinyamalale ngokuphelele ngemva Isikali zincishiswe noma ukuqedwa ngokuphelele ukusetshenziswa kwalesi izidakamizwa, futhi uma kufaneleka libuyisele electrolyte nasoketshezini zizonikezwa, okuyinto kufanele kwenziwe ngaphansi kwezimo lokulawula esiphezulu. Torasemide neze lisuselwa ngegazi hemodialysis.

Lona ulwazi oluyisisekelo mayelana "Torcida" ukulungiselela (yokusetshenziswa, intengo, ukubuyekezwa). Analogs ithuluzi ( "Britomal", "Sutrilneo") ezimweni eziningi ziyahluka efanayo isinyathelo futhi side effects, kodwa liyindlela lodokotela ngokuvamile ababelwe kuzo njengoba omunye ephumelela kunazo eqenjini layo.