Antidepressant 'Azafen', yokusetshenziswa, imiphumela emibi

Izidakamizwa "Azafen" libhekisela eqenjini le tricyclic antidepressant. It has a sine okusezingeni eliphezulu, anxiolytic nemiphumela antiaggressive. Lesi sidakamizwa kabanzi ekwelapheni wamaphaphu ayimigodi yesibili, njenge:

- endogenous;

- astenodepressiya;

- exogenous;

- oludakayo;

- alamu;

- isimo phakathi kwezimo ukuphathwa kwabathintwayo bemvelo ezingamahlalakhona.

Isithako asebenzayo zomuthi "Azafen" incazelo libhekisela pipofezine. Lo mshini wezenzo into esekelwe okusithiyayo of abatholako neuronal ka norepinephrine kanye le-serotonin. Lokhu kuholela ekwandeni lokuhlushwa pipofezine ku CNS futhi izimpawu bacindezeleke ukunqampunwa.

Kukhona omunye inzuzo phezu izidakamizwa ezifanayo antidepressant izidakamizwa action "Azafen" yokusetshenziswa libhekisela ukungabi khona imiphumela yako cardiotoxic. Kuyaqapheleka njengomuntu ongaba namava amahle kusho "Azafen" ku iziyaluyalu affective, buthaka iziyaluyalu le ukuphathwa kwabathintwayo, ngemilingo futhi autonomic ezihlobene nokucindezeleka. kusebenta okuphezulu "Azafen" imfundo manual ichaza ngokumelene asthenia, ukuxakeka ezivukayo ngenxa psyche womuntu ukuphathwa kwabathintwayo. Phakathi nesimiso sokuqondisa izidakamizwa iziguli ubalekela nokukhathazeka, ukucindezeleka. Dynamics Positive in iziguli sokuzincisha ukudla, ukulala evamile futhi ukozela ubalekela emini.

Medicine "Azafen", ezisuselwa kuzakhiwo zalo pharmacokinetic has digestibility ezinhle, it is kahle bumuncwa ipheshana wokugaya ukudla, has bioavailability okusezingeni eliphezulu (80%), esiphezulu igazi lokuhlushwa ifinyelela kakade ngaphakathi 2 amahora. Esikhathini isibindi kwenzeka biotransformation pipofezine ukuba ezigcemeni metabolites ukuthi ziboniswa nezinso. Ukukhululwa Ngokugcwele zomuthi kusukela umzimba kwenzeka phakathi namahora angu-16.

Ukwelashwa zokucindezeleka zasezindaweni ezihlukahlukene kuyinkomba okuyisidingo ukusetshenziswa imanuwali izidakamizwa "Azafen" imfundo icacisa isimo, sibhale zonke izinhlobo depressioy, wadalula izidakamizwa.

Kukhona Izimo eziningana ukuthola antidepressant "Azafen" yokusetshenziswa ukuze ukhombise uthi abalandelayo uhambisane ukwelashwa izidakamizwa:

- sikashukela;

- ukwabelana nge mao inhibitor ;

- esivimba amanzi infarction, ukuhluleka kwenhliziyo, yenhliziyo Umthambo isifo;

- hepatic noma ukwehluleka kwezinso;

- isifo esithathelanayo, ezinzima;

- isimo ngemuva izingozi cerebrovascular sina (stroke);

- Ukukhulelwa, lactation.

Kufanele siqaphe ukuba okuvela kungenzeka amathuba okuba nemiphumela engemihle ngesikhatsi ukwelashwa, basuke esashiwo isiyezi kanye ikhanda, nokungezwani komzimba nezinto, ukuhlanza kanye nesicanucanu. Ngeshwa, akukho ulwazi mayelana nokwelashwa uma izidakamizwa ukweqisa izidakamizwa, nangaphansi kwezimo ezinjalo, kuthatha lingaze. Mayelana nodaba Izimo kufanele ukungezwa inkinga efanayo "Azafen" kanye notshwala. Lezi ezimbili imiqondo ngokuphelele alizimele ngesikhatsi ukwelashwa kufanele inqanyulwe utshwala kanye reception kanyekanye amalungiselelo equkethe ethanol.

I "azafen" akatholakalanga izakhiwo anticholinergic, ngakho ungadikibali ukwelashwa izidakamizwa iziguli glaucoma. Ngaphezu kwalokho alihambelani utshwala, kukhona ingozi isicelo ngesikhathi esisodwa izidakamizwa ne anticoagulants, antihistamine nazo zonke izidakamizwa, CNS depressants. Sicela uqaphele ukuthi reception ngesikhathi esisodwa "azafen" nezidakamizwa antiepileptic ukunciphisa ukusebenza lakamuva.

Khishiwe "Azafen" ngokuqinile ngokuvumelana iresiphi, esiphezulu eshalofini ukuphila iminyaka 5, kufanele ligcinwe ngaso tmax 25.