"Diferelin": ukubuyekezwa, analogs, futhi yokusetshenziswa

Eminye yemithi ngempumelelo aklanywa zokunqanda zokugula okunzima kwabesifazane nabesilisa uhlelo zokuzala, buyisidakamizwa "Diferelin". Umyalelo, intengo yaleli izidakamizwa ngokuvamile ukuxoxa iziguli izinkundla ezikhethekile. Njengenjwayelo, futhi lokhu izidakamizwa has abasekeli bayo nabaphikisi. Kulesi sihloko sizoxoxa lo mshini wezenzo yalesi izidakamizwa kanye nezici zayo kwemithi.

zokwelapha

Ukulungiselela "Diferelin" buyisidakamizwa nge antigonadotropnym senzo. Empeleni, kuba anti-hormone, njengoba unekhono ukucindezela ukukhiqizwa luteinizing kwama-hormone i-hormone follicle-inkanuko e insikazi ne-testosterone amadoda. Ngakho-ke, "Diferelin" izidakamizwa wokusetshenziswa okusebenzayo ukwelapha lesizalo fibroids, i-endometriosis, umdlavuza wesinye, ukuthomba ekuqaleni intsha kanye nezinye izifo.

Sakhiwo Ukwakheka

Ukulungiselela "Difelerin" okwamanje lutholakala kuphela ngomthamo ifomu elilodwa - lyophilisate uzenzele. Ngesikhathi esifanayo, kwenza ezintathu izinhlobo amathuluzi, lokuhlala ehlukene efana asebenzayo nokuba ngezinhloso ezehlukile:

• "Diferelin" 11,25 mg kanye 3,75 mg - ujove esicutshini;
• "Diferelin" 0.1 mg - I-umjovo ongama.

Iyasebenza, odokotela kanye neziguli nje ukubizwa ngokuthi izinhlobonhlobo ezilandisiwe izidakamizwa, okwenezela isihloko izibalo echaza okuqukethwe ketshezi main.

Njengoba isithako asebenzayo imithi "Diferelin" izilinganiso okuyinto ogxile omuhle izenzo triptorelin pamoate. Lokho-ke enalo isiguli liphinyiselwe imiphumela zokwelapha kanye kwemithi.

Nomuthi "Diferelin" edayiswa amabhokisi, lapho kukhona amabhodlela lyophilisate futhi isipetu nge izinaliti ezimbili. Ngaphezu kwalokho, wabeka izitsha eziyisikhombisa kuphela. Kungaba ezahlukene. Uma lyophilizers "Diferelin" 3,75 futhi 11,25 mannitol isetshenziswa okungcono, lo nomuthi e lokuhlushwa 0.1 mg elisetshenziswe kaningi nosawoti.

umphumela zokwelapha "Diferelin"

Ngokombono kwamakhemikhali-hormone okuthiwa i asebenzayo izidakamizwa kuyinto analog we ngxenye GnRH kwemiqondo. Kuthinta indlala pituitary unesibopho ekukhiqizweni kwama-hormone ocansini, ngaleyo ndlela olawula umsebenzi we kwabesifazane nabesilisa uhlelo zokuzala: indlala wendlala yabesilisa, esibelethweni, kwesibeletho, amasende. It kuvela ukuthi ulawula ukukhiqizwa ubulili-hormone imithi "Diferelin".

Izibuyekezo sokusebenza kwawo zisikisela ukuthi has a anti-isimila nendlala okuthiwa i antigonadotropnym isinyathelo esiqatha futhi ngempumelelo ekwelapheni pathologies ezithile. Ngokwesibonelo, ukungazali, lo muthi suppresses ukukhiqizwa luteinizing-hormone okuthiwa i Uphatha kabi nge-ovulation, ngaleyo ndlela kwande amathuba okukhulelwa. A nomuthi umdlavuza wendlala yabesilisa, lokhu kunciphisa amazinga testosterone zero, okuyinto sici for castrates, futhi kwandisa amathuba yokuthi ogulayo uphelelwa ukususa umdlavuza.

magic Ngempumelelo "Diferelin" futhi i-endometriosis. umthelela wabo ekukhiqizweni kwama-hormone ocansini kancane kancane ingena owesifazane esimweni yokufakelwa of menopause futhi kanjalo kuphakamisa yoma endometriodnyh foci.

izinkomba

Kuye lokuhlala nemiphumela ehlukene kwi umzimba izidakamizwa "Diferelin". Ukusetshenziswa kwalesi izidakamizwa kule imithi kuncike okuqukethwe kule isithako esikhulu. Ngokwesibonelo, umjovo "0.1 mg Diferelin" kuboniswe ukungazali, ngokuba nalomsebenzi ukushukuma wesibeletho kanye nge-ovulation e-IVF.

Ukusetshenziswa kwalesi izidakamizwa ngesikhathi lokuhlushwa 3,75 mg uyelulekwa lapho sisebenzelana umdlavuza wendlala yabesilisa, fibroid kwesibeletho, yokuvuthwa ngaphambi kwesikhathi, esithweni sangasese futhi endometriosis extragenital, IVF yezifiso.

Esikhathini ezimweni ezibucayi kakhulu umdlavuza wendlala ne metastases futhi endometriosis okungamahlalakhona, esimisiwe reception "Diferelin 11,25 mg." Ukusetshenziswa Its kungaba ngokuphawulekayo ngcono amathuba lesiguli zokululama.

Yokusetshenziswa

Medicine "Diferelin 0.1 mg" isetshenziswa lamafisha IVF yezifiso ngaphansi kweso lwezokwelapha esiqinile. Iqondiswa nsuku zonke umuntu ampoule kusukela ngosuku zokwehlukaniswa yesibili. Isikhathi salesi ukwelashwa kunqunywa izici ngazinye umzimba female.

Kodwa izidakamizwa "Diferelin 11,25 mg" iqondiswa iziguli njalo ngemva kwezinyanga ezintathu. Futhi amadoda ungenza umjovo nganoma yisiphi isikhathi, futhi abesifazane - kuphela ezinsukwini ezinhlanu zokuqala nomjikelezo wokuya esikhathini. Ubude yokwelashwa nale izidakamizwa Uthatha izinyanga ezintathu kuya kweziyisithupha, njengoba izinyanga ezingaphezu kweziyisithupha, it is hhayi Kunconywa.

Ububanzi okubanzi izicelo kwezokwelapha "Diferelin 3,75". Nobufakazi ukukhombisa ukuphumelela kwalesi izidakamizwa. Ngaphezu kwalokho, kulula kakhulu ukuyisebenzisa, ngoba ayidingi ekuphathweni nsuku zonke isikhathi eside. Imijovo "Diferelin 3,75 mg" zomuthi ngokuvamile kwenziwa kanye ngenyanga. Lena okwanele ukuqinisekisa ukulethwa izinto asebenzayo emgudwini wegazi ngesikhathi imithamo zokwelapha. Ake sicabangele isicelo sale nomuthi wesifunda izifo ezihlukahlukene.

umdlavuza wendlala

Amadoda aluboniswa ngoba umdlavuza wendlala ikhambi "Diferelin". Imijovo isiguli ezibekwe zonke izinsuku ezingamashumi amabili nesishiyagalombili, ukuze isikhawu phakathi nesimiso sokuqondisa izidakamizwa amasonto amane. A umthamo owodwa we-nomuthi isicelo - omunye umfuma 3,75 mg. Isikhathi izidakamizwa ekuphathweni kunqunywa izinga sokuphulukiswa isiguli.

i-endometriosis

Imijovo zomuthi "Diferelin" abesifazane nge endometriosis atholakala kulamalanga ekucala lasihlanu elilandelayo esikhathini. A umthamo okwalandela imithi akhiqizwa emasontweni amane, futhi izifundo nqubo yokwelapha ithatha bangu-3 kuya ku-6 izinyanga. Kufanele kukhunjulwe ukuthi le izidakamizwa ayikwazi kuhlanganiswe nokusetshenziswa zokuvimbela inzalo ngomlomo.

Ekwelapheni endometriosis kubangela menopause yokufakelwa (amenorrhea) ukulungiselela "Diferelin". Nokho, ku- iziguli, abonisa ukuthi emva ukumisa ukwelashwa umjikelezo wokuya esikhathini uwubufakazi kubuyiselwa ezinyangeni ezimbalwa, ngezinye izikhathi ngonyaka. ukwelashwa okuphindaphindayo nale imithi nge endometriosis yansukuzonke, njengoba umthetho, is alinikeziwe - le njongo, ezinye, nemithi ayisasebenzi.

Adrenarche

Izingane ezobopha nisebancane ukuthomba izidakamizwa "Diferelin" iqondiswa sinye njalo ezinsukwini ezingu-28. Ngakho umthamo owodwa we isicelo ibalwa kusukela isisindo sesiguli. Izingane nge isisindo phezu 20 amakhilogramu wasungula isitsha (3.75 mg), kanye nezingane kanye indices ezincane - isigamu ampoule (1.875 mg). Isikhathi yokwelapha kunqunywa udokotela ukuba khona ngokuya ngesivinini we ukuzinza kwesimiso lesiguli.

lesizalo fibroids

In the ukwelashwa kwalesi sifo iqondiswa kanye ngenyanga umuthi ibhodlela elilodwa "Diferelin". Futhi reception yayo kufanele kwenziwe phakathi nezinsuku zokuqala ezinhlanu umjikelezo wokuya esikhathini uwubufakazi isiguli. imijovo Okwalandela zomuthi zenzeka njalo emavikini amane. Isikhathi yokwelapha uqobo esingaphansi kwezinyanga ezintathu.

ukweqisa izidakamizwa

Okwamanje ayivezi Kunoma yikuphi imithi "Diferelin" ukweqisa izidakamizwa. Nobufakazi futhi abonisa nokuphepha yayo isihlobo. Ngaphezu kwalokho, izidakamizwa akunamthelela le lokuhlushwa futhi ikhono ukulawula izindlela zokuthutha. Ngakho-ke, phakathi ukwelashwa ngalo muthi kuphephile ukushayela.

side effects

Uma usebenzisa "Diferelin" isidakamizwa bangezwa ohlangothini imiphumela elandelayo:

• Izimpawu ze-umgogodla intambo kokucindezelwa;
• ubuhlungu owandiswayo;
• Angioedema, urticaria, ukulunywa;
• ureteral isimiso;
• ikhanda;
• ithambo demineralization;
• kwehle potency;
• isitho sowesifazane somile;
• ajulukayo;
• nokwehlisa testes;
• izinguquko usayizi webele;
• amenorrhea hypogonadotropic;
• hypertrophy ezikhiqiza amaqanda;
• menorrhagia;
• asthenia;
• ukucanuzela kwenhliziyo, ukuhlanza,
• nomfutho wegazi ophezulu;
• komzimba;
• angaboni kahle ;
• lability ngokomzwelo;
• hematuria;
• ukuvela isisindo okweqile;
• edema neuropathy;
• umkhuhlane;
• sokuzincisha;
• nokucindezeleka;
• tachycardia;
• Alopecia;
• dyspnea;
• ububomvu kusayithi umjovo;
• paresthesia.

Izimo

Esikhathini izidakamizwa "Diferelin" Kukhona ezinye Izimo ukusetshenziswa. Zihlobene isimo lesiguli zempilo, kanye nezici zayo ngazinye bokuphila. Ngokwesibonelo, amadoda awukwazi ukuthatha lesi imithi nge-hormone ezimele umdlavuza wendlala futhi emva ukususwa emasendeni, futhi abesifazane is hhayi Kunconywa ngesikhathi sokukhulelwa, ibele, futhi polycystic syndrome esibelethweni. Wonke umuntu, ngaphandle kokukhetha, udinga ukusebenzisa izidakamizwa ngokuqapha "Diferelin" ukukhumuzeka kwamathambo kanye hypersensitivity kuya izingxenye zalo. Uma kukhona izimpawu ezingathandeki, isiguli kufanele ngokushesha kudokotela.

isimo Jikelele emva isicelo

Njengoba kushiwo ngenhla, lesi sidakamizwa "Diferelin" ithiya ukukhiqizwa kwe-hormone ocansini kubantu besilisa nakubantu besifazane, kanjalo ukubethula esimweni castration yokufakelwa. Ngokusobala, ukucwiliswa esesimweni esinjalo futhi okukhiphayo yalo ihambisana ezingokwengqondo, endocrine-umzimba kanye Neuro-vegetative kwempilo.

Ngemva kokuphothulwa yokwelapha nale hormone nemithi abuyiselwe, kodwa phakathi nale nqubo ingase yibe yinto exakayo isiguli ukucasuka, ukukhathala, ukuphathwa ikhanda, ukujuluka, ukushisa komzimba, ukucindezeleka, imfiva kanye nezinye izimpawu ezingezinhle. Nokho, ezinyangeni eyodwa nengxenye ngemva kokuphela izidakamizwa isimo lesiguli ngokomzimba kungokwemvelo ngokuphelele. Okungukuthi, ngokuvamile emva umjovo zokugcina "Diferelin 11,25 mg" i-hormone ibhalansi kubuyiselwa emva kwezinyanga ezingu-4.5, futhi isenzo izidakamizwa ngesikhathi lokuhlushwa 3,75 mg kuphela ngemuva kwezinyanga 2.5. Kulezi ezithiwa e abesifazane futhi amadoda ngokugcwele avuselelwa umsebenzi wokuzala kanye nokuya ocansini futhi libido kuza emuva evamile.

ukukhulelwa

Lapho ingane esindayo ukwelashwa "Diferelin" contraindicated. Nokho, lo muthi kabanzi ukuthuthukisa ukukhiqizwa kwamaqanda. Abesifazane abaningi bayakwazi ukhulelwa emva imijovo eziningana zomuthi, kodwa engazi, baye baqhubeka ukuthatha imithi "Diferelin". Umthelela kulo muthi uyakwazi ukusungula, akusho ukulimaza umntwana ongakazalwa: hhayi kumkhathaze ingozi kwesisu kanye ungakuvumeli ukuba ukuthuthukiswa kombungu esizalweni. Nokho, lo mshini wezenzo izidakamizwa ku insikazi uhlelo zokuzala ngesikhathi sokukhulelwa usadinga Ukutadisha ngokucophelela.

Izidakamizwa analogue "Diferelin"

Ngesikhathi ezithaka imithi emakethe wamanje kukhona engazweli lahlotshaniswa eyodwa kuphela, ukuba ukubunjwa yayo isithako efanayo esebenzayo - kuba "Dekapeptil". Ngaphezu kwalokho, Pharmacy zingatholakala izidakamizwa kokuthi siletha imiphumela efanayo zokwelapha njengoba izidakamizwa "Diferelin". A nomphumela ofanayo emzimbeni inikezwa yi: fafaza "Buserelin" lyophilisate "Buserelin Depot", "Zoladex" capsule ukwakhiwa "Eligardt" futhi "Lyukrin Depot".

Izibuyekezo

Kukhona zombili okubuyayo omubi ukusetshenziswa kwemithi "Diferelin". Imijovo yalesi izidakamizwa nemiphumela ehlukene kwi iziguli. Nokho, abesifazane abaningi ngisho wambona imakwe nomphumela oqabulayo in ephulukisa fibroids nezinye izifo, ukukhononda okuba nemiphumela engemihle ukuthi kabi ikubekezelele nabo indlela yokwelashwa: kwesisindo komzimba, ukucasuka, ukukhathala. Ngesikhathi esifanayo, zonke iziguli uyavuma ukuthi kunzima yokwelapha uhlolo lwezidakamizwa namanje akukhetha ukuhlinzwa ingaphakathi.

Ekwelapheni umdlavuza wendlala nezinye pathologies ezingabantu futhi zenzeka Izibuyekezo okuxubile on imiphumela izidakamizwa "Diferelin". Intengo zomuthi abaningi babonakala indlela eyamukelekayo kwesicelo akulona eyanelisayo, nokuthi kuyaphumelela futhi ingabe sakhiwa izinkondlo wokudumisa, ngoba hhayi kuphela kususa isimila ngokwayo, kodwa futhi aqede metastases emathanjeni. Nokho, kukhona Izibuyekezo ezingezinhle mayelana nemithi "Diferelin" izizathu ngenxa ezimbili eziyinhloko: izidakamizwa abampofu ukusebenza ezimweni ezithize, futhi imiphumela emibi ukuthi kabi ikubekezelele ezinye iziguli futhi kubangele ukuba angaqhubeki yokwelapha noma iwe ngokuphelele aphume isigqi evamile yokuphila.

amanani

Kuyini izindleko umuthi "Diferelin"? Intengo lomutsi luyehluka kuye ngokuthi ezihlukahlukene, ekhemisi uchungechunge, lapho bayidayise, futhi ngomphetho wekhasi kulokho izimpahla. Ngakho, emakethe Inani lamanje le izitsha eziyisikhombisa eziyisikhombisa "Diferelin 0.1 mg" ububanzi ruble 2597-3107. Isikali Iningi kuzodinga ukutshalwa lubucayi kakhudlwana: 1 ibhodlela "Diferelin 3,75 mg," umthengi kuyodingeka bakhokhe kusuka 7632 kuya ruble 9076. Ngokwemvelo, lokhu kusho izidakamizwa eqolo kuyinto okuhlushwa okukhulu. Omunye ampoule "Diferelin 11,25 mg" angathengwa 18 269-23 100 ruble.

Kunalokho okusezingeni eliphezulu yilona inani lentengo lomuthi "Diferelin". amathuluzi Okufanayo ishibhile, kodwa isivumelwano sabo sokuhlangana singamethemba kuphela udokotela abanolwazi, ngoba anezici kwemithi ezihlukene kakhulu, contraindications engemihle.

isiphetho

Manje ngoba sewuyazi ukuthi konke mayelana "Diferelin" izakhiwo zomuthi. Lesi sidakamizwa hormone ngempumelelo ezifweni eziningi, kodwa kungase kubangele eningi engemihle. Ngaphambi kokuqala ukwelashwa, isiguli ngasinye kufanele izilungiselele yokuthi ukwelashwa okunjalo kungaba inselele enzima ngaye. Nokho, noma yimuphi ingozi buyafaneleka, uma sengozini kuyinto impilo futhi ngezinye izikhathi ukuphila komuntu. Ngakho ungadikibali ukusetshenziswa kwezidakamizwa "Diferelin" noma esikhundleni salo analogue eshibhile. Kungcono ukuqala ukwelashwa nge izindlela eziphumelela kakhulu futhi ngaleyo ndlela ukuqinisekisa ukuthi umphumela omuhle. Hlala uphilile!