Lapho DHT liphakeme e abesifazane futhi amadoda?

Dihydrotestosterone (5a-DHT) kuyinto steroid anamandla, empeleni yayo efana testosterone futhi androstenedione. DHT kwabesifazane ikhiqizwa androstenedione ezingabantu - kusukela testosterone. Esikhathini zamagama le-hormone kuhileleke futhi enjalo-enzyme ezibalulekile njengoba 5-alpha reductase.

ukuguqulwa umzimba kwe-testosterone ku DHT kwenzeka izicubu testes besilisa, phakathi kokunye, in the wendlala. Hormone elawula ukwakheka emangqamuzaneni endlaleni engasesinyeni futhi epithelium yayo linendima ebalulekile ekwakhiweni yemisipha ngesikhathi ukukhula kanye nokuvuthwa we umzimba besilisa umsebenzi wakhe ngokocansi. yehlise amazinga testosterone futhi dihydrotestosterone kuvusa Inkulumo yokungabi namandla ezingabantu.

Njengoba kuba DHT ecacile kungokwalabo hormone ocansini besilisa. Futhi umbuto bese uyavuka, kungani amahomoni wesilisa edingekayo umzimba besifazane? Noma kunjalo, zidlala indima ebalulekile kakhulu empilweni yowesifazane.

DHT kwabesifazane

Ukuze ekukhiqizweni kwama-hormone, kuhlanganise besilisa - androgens kwabesifazane umzimba ukuhlangabezana nezindlala adrenal. Of androgens e umzimba female zonke zikhona emihlanu - sulfate dehydroepiandrosterone, androstenedione, DHEA, testosterone futhi dihydrotestosterone. Kulokhu, kuphela testosterone uyakwazi nomphumela ngqo ezithweni zesifazane nezicubu. Zakhe zokuqala ezintathu ziphathelene pro-hormone, ngakho umsebenzi wabo kungaba, kuphela ephendukela testosterone. Dihydrotestosterone ngokuphambene, liwumkhiqizo testosterone umzimba.

Kukho konke ukuphila kwakhe, amazinga ngayinye androgens emzimbeni yabesifazane ziyashintsha. Uma sikhuluma dihydrotestosterone, the esiphezulu Inkomba waligcina phakathi nenkathi yokuthomba, lapho amantombazane aqala ukuvela izici yesibili ngokocansi - webele ukukhulisa, ukubukeka izinwele pubic, njll Ngakho, androgen empeleni wonke amanye "uthole ndawonye". obhekene nentuthuko ngokobulili ofanele umzimba female.

Uma dihydrotestosterone liphakeme besifazane, kuye ngokuthi yobudala, okungenzeka pochvlyaetsya izimpawu hyperandrogenism: hirsutism (izinwele zikhula zibheke ngakhona ku umzimba wonke noma izingxenye ngazinye ke), Clitoromegaly (ukukhulisa clitoral), induna. Yandisa ka dihydrotestosterone entsheni e amantombazane angaba babangela aphuthelwe nezikhathi, ushona kwezwi nokuthuthukiswa lwamathambo ohlobo besilisa. Eminyakeni eyalandela dihydrotestosterone kwaphakanyiswa abesifazane kungaba, uma kukhona nezinwele, ukungazali kanye nezinye izinkinga eziningi. Noma kunjalo, ukwanda amazinga DHT kungenzeka kancane njalo - kuphela 5-8% abesifazane.

DHT ezingabantu

In amadoda, ukwanda igazi DHT kungabangela Hyperplasia we wendlala kanye ukubukeka umdlavuza. ukwanda kwe-testosterone endogenous ikhuthaza esasizosheshisa kwemisipha ukukhula, nobumpandla induna esikhumbeni. Lokhu kungenxa ukuthomba kom , futhi Hyperplasia adrenal e intsha. Ngesikhathi esifanayo, ngokungafani testosterone, dihydrotestosterone has a uxhumano obuseduze androgen yokwamukela kwezicubu. Ubuningi eliphakeme ekhona isikhumba umthondo kanye follicle izinwele. Ngakho, uma ileveli dihydrotestosterone kungenzeka impandla noma okuphambene, ngokweqile izinwele ukukhula emzimbeni.

Izinga yama-hormone abafana bancipha ngesonto lokuqala emva kokubelethwa, kwandisa ekupheleni enyangeni yesibili ekuphileni, bese aphinde encishisiwe kancane. ukwanda kwalo isivele phezu ukufinyelela ukuthomba umfana ukuthi kubonakala kahle hhayi kuphela ukuhlolwa igazi, kodwa futhi isimo esikhunjeni. Amantombazane kancane kancane ekunqabeni amazinga ama-hormone, eziqala ngenyanga yokuqala yokuphila futhi prepubertal bese uqala ukwandisa. Phakathi nenkathi yokukhulelwa, njengoba umthetho, lizinga dihydrotestosterone kuyehla. Uma ngalesi sikhathi anda DHT e Kwabesifazane, kunesibonelo awokuthi okuvela thrombophlebitis futhi adrenoblastomy.

Inhloso DHT-hormone okuthiwa i

Ezimweni lapho DHT lehliselwa e abesifazane, ke unendawo zinsiza zayo. Izimpawu I-dihydrotestosterone (DHT) kuyinto ukuntula kwakhe azalwa naso, hirsutism, kwehle libido, ubuthakathaka ezingabantu, nokunye. Ngu control esiqinile zomuthi lingasetshenziswa ekwelapheni ingozi isimila Prostatic.

I-hormone DHT kubalulekile ekwakhiweni isimiso sezinzwa esiyinhloko, amangqamuzana ezinzwa ebekelwa receptor androgenic. DHT kuyabathinta anamandla angaphezu kuka-testosterone. Ukuthola la ma-hormone kusekela kukhula Izinzwa cell zemizwa umzimba amahora angu-24. Ngokusho ososayensi abathile, lomkhuba kungenxa ukukopisha zofuzo iketango DNA.

Ithonya DHT ku isimiso sezinzwa esiyinhloko futhi imisipha yohlaka ivumela abasubathi ukwandisa impumelelo kwezemidlalo, umzimba ukuzivumelanisa ukuqeqeshwa sithuthukiswe nokwakha yemisipha. Ngokuvamile abadlali ungezwa izikhalazo mayelana kancane kwemisipha ukukhula ngenkathi ethatha le mithi. Kulokhu, kungase kuhlotshaniswe nge iqhaza inqubo nezinye hormone ekhiqizwa umzimba kanye nokunciphisa testosterone isinyathelo ezivikela. Kunoma ikuphi, DHT akufanele kubhekwe njengendlela hormone ebangela engemihle.

Norm ka DHT emzimbeni nomuntu wesilisa omdala kubhekwa inkomba 250-990 pg / ml kwabesifazane - 24-450 pg / ml. Kunezindlela eziningana izifo lapho DHT liphakeme e abesifazane futhi amadoda njalo igazi. Lezi zihlanganisa:

• hirsutism, uhlobo oluthile izimila cortex adrenal;
• adrenoblastoma nemfundo thrombophlebitis lapho ukhulelwe;
• ekstragonadnoe unesimila virilizing isimila wesibeletho ngabantu;
• feminization wamasende.

Ngu ukwehlisa izinga DHT egazini, izifo ezifana kungenzeka:

• gynecomastia;
• Down Syndrome;
• ukuhluleka hepatic;
• ubuthakathaka;
• myotonic sokuwohloka kwemisipha kanye nezinye izifo eziningi.