Prednisolone: yokusetshenziswa, izakhiwo kwemithi

Khipha ifomu "Prednisolone" izidakamizwa: amafomu okwelapha ezithambile - wamafutha.

Farmsvoystva

Prednisolone kuyinto analogue dehydrogenated of hydrocortisone. Antiallergic, antiinflammatory, umphumela antiexudative futhi antipruritic uma kusetshenziselwa ihlelwe ngokulandelana kwezihloko wamafutha "prednisolone" imfundo kubangela ukwehla ukwakheka, ukukhululwa kanye umsebenzi ukuvuvukala balamuli (kinin, a histamine, ama-enzyme lysosomal, prostaglandins). Futhi OAmaKristu iseli ukuthuthela eshayeka ukuvuvukala incipha vasodilation futhi ngakhula semithambo permeability ezenzeka ukuvuvukala. Ukunciphisa exudation kungenxa isenzo vasoconstrictor ka "Prednisolone" izidakamizwa. Manual ibonisa ukuthi izidakamizwa kumphumela immunosuppressive ngu ezivimbela isenzo eziyinkimbinkimbi antigen-omzimba futhi ukuqongelela phezu Imithambo yegazi futhi imbangela vasculitis nomzimba. Umuthi kuvimbela isenzo macrophage, cytokines, kuhlose amaseli ezibangela ukuthuthukiswa iguliswa ukuphendula uhlobo dermatitis esithathelwanayo. Ngakho batiswe T-lymphocyte futhi macrophage angeke uthole ukufinyelela kuhlose amaseli.

Pharmacokinetics

Lapho isicelo wamafutha "Prednisolone" wakwamukela futhi ketshezi asebenzayo esegazini. Ngo-plasma prednisolone eside part okuhlobene albumin futhi transcortin. Biotransformation prednisolone kwenzeka namachibi, ikakhulukazi isibindi, lapho glucuronidation noma sulfation kwenzeka amafomu Oxidized. Ngesimo metabolites excreted ku umchamo kanye endleni, ingxenye - esimweni unmodified. Prednisolone sidlula isithiyo esinomhlapho e lokuhlala ezincane, kungatholakala obisini lwebele abesifazane.

Prednisolone: Ubufakazi

Umuthi isetshenziswa amacala:

- iguliswa futhi ecasulayo contact dermatitis,

- eczema,

- atopic dermatitis,

- seborrheic dermatitis,

- psoriasis.

Prednisolone: imfundo

Namafutha sisetshenziswa kusayithi isilonda ngokulinganayo izikhathi 1-3 / usuku. Ubude besikhathi sokwelashwa kubangelwa ubunjalo isifo futhi kuvame ukuthatha izinsuku 8-14. Wamafutha ekwelapheni izingane isikhathi sokwelashwa kufanele ibe ngu- 3-7 izinsuku, kusukela umzimba somntwana bazwelane kakhudlwana izidakamizwa "Prednisolone". Ukufundiswa uncoma ukulahla ukufudumala, ukulungisa kanye kusaladi occlusive.

Izici isicelo

Ubude yokwelashwa ngamafutha akufanele kube izinsuku ezingaphezu kwezingu-14 ukuze kuvinjelwe imiphumela engemihle evela ukusetshenziswa "Prednisolone" izidakamizwa. Ukufundiswa sinquma ukwelapha kuphela ngaphansi kweso lwezokwelapha.

side effects

Ngokuvamile umuthi kahle ibekezelelwe. Akuvamile, ikakhulukazi ngemva ukusetshenziswa isikhathi eside, kungase kubangele ukulunywa, evutha ukuzwa, erythema. Kwezinye iziguli imiphumela emibi bangase balwisane njengoba folliculitis, hypertrichosis, dermatitis perioral, komzimba nezinto izingxenye imithi. Izimpawu ngenhla asidingi ukwelashwa kanye isuswe ngokushesha ekunqanyulweni kwesicelo zomuthi. Kufanele kukhunjulwe ukuthi isicelo amafutha esikhunjeni ethintekile kanye nokusetshenziswa eside (ikakhulukazi kokunqotshwa izindawo ezinkulu isikhumba) zingavela imiphumela emibi ngesimo letindzala.

Ukusebenzisana neminye imithi

Prednisolone has impahla ukukhuthaza ukusebenza anticoagulant ka anticoagulants. It kwandisa kungenzeka ukopha uma uthatha salicylates. It kwandisa amathuba electrolyte umzimba iziyaluyalu nokuphathwa concomitant of isisu. Kunengozi elikhulayo ubuthi uma usebenzisa glycosides inhliziyo. Kwehliswe umphumela hypoglycemic antidiabetic kunciphe umsebenzi elwa namagciwane of rifampicin. Akunconyelwe ukusetshenziswa ngokuhlanganyela antacids.

Izimo

Ukwelashwa "Prednisolone" imfundo wamafutha akuvunyelwe ku:

- hypersensitivity;

- webhaktheriya, viral, fungal Izilonda;

- sofuba, ugcunsula, isikhumba izimila, ukukhulelwa, induna ezivamile futhi induna pink.

ukweqisa izidakamizwa

Amacala ukweqisa izidakamizwa akwaziwa.

izimo isitoreji

Egcinwe ohlwini B, ngesikhathi 5-15ºS. Impilo - iminyaka 2. Ekupheleni kwesikhathi ekuphileni eshalofini hhayi ukuyisebenzisa.

izimo ukunikezela

Ukunikezwa Imvume Yokuthola Umuthi.