ImpiloImithi

ACTH (hormone) - kuyini? ACTH

Umsebenzi umzimba kusekelwe nokuxhumana zonke izingxenye zawo abamelwe - izicubu kanye izitho. Nokho, nabalawuli eyinhloko imisebenzi yabo yilezi izinto eziphilayo isakhiwo ezahlukene. Letakhi zihlanganisa ama-hormone. Enye yalezi izinto kuyinto adrenocorticotropic ezibalulekile (noma ACTH) hormone.

ACTH (hormone) - kuyini

Le into kuveza indlala pituitary - main endocrine indlala onesibopho sokwenza cishe yonke imisebenzi. Ukuze kukhiqizwe ACTH ukuhlangabezana amaseli eosinophilic we pituitary anterior.

Kuhunyushwe kusuka egameni lesiLatini hormone ngokoqobo kuzwakala "okuhlobene nezindlala adrenal." Ukudlulisela enomopho kubo, ketshezi uqala ukusebenza kwalezi nezindlala, ekhuthaza ukuthuthukiswa ejenti ethize adrenal. Lo mshini wezenzo hormone lezi nezindlala kuhloswe ukusebenza cishe zonke izindlela zokuzivikela ngenkuthalo kuzibonakalisa ngaphansi kokucindezeleka.

Ngu uqobo, ACTH kuyinto molecule amaprotheni. isakhiwo salo ngempela eziyinkimbinkimbi: it has izigaba eziningi, ngayinye yaba wenza umsebenzi othile (uxhumano receptor ethize, kuzole umsebenzi kwezitho, unesibopho umphumela immunogenic).

Into uyalalela a isigqi lomzimba, okungukuthi ngesikhathi emakamu yayo mkhulu kunezinhliziyo kwezinye izikhathi.

biosynthesis

Njengoba ACTH kwemiqondo (hormone)? Ukuthi kuyini, kunzima ukukuqonda lokhu ngoba i-molecule ye futhi ngokuhlanganisa izakhi amaprotheni (ama-amino acid) neqembu hydroxyl (-OH), kanye izici ama biogenic (-NH2). Njengoba iningi molecule neketanga amino acid izinsalela ukuthi evamile kubhekwa ukuba peptide noma amaprotheni.

Ingqikithi is umqondo kusuka okuthiwa eyandulela amaprotheni. Njengesisekelo synthesis pro-opiomelanocortin-hormone okuthiwa i-molecule izenzo.

i-hormone Adrenocorticotropic, njengoba sekushiwo, ikhiqizwa uxhumano ne isigqi lomzimba, okungukuthi isikhathi sosuku. , The zamagama kubuye sincike-hormone okuthiwa i - corticotropin (ukuqala i-hormone hypothalamic obhekene nokucupha le pituitary). Corticotropin ngenkuthalo ikhiqizwa 6 ekuseni kuya ku-9 ekuseni, futhi nenombolo ezincane kunazo zonke yalo nasemkhakheni igazi kuka-19 no 23 amahora. Kuye lokhu, futhi variruetsya inani ACTH egazini.

Iqhaza le-hormone

Njengoba kushiwo, i-hormone adrenocorticotropic unesibopho umsebenzi nezindlala adrenal. Ukuthola uwayisa zabo, i-hormone ezizokhuthaza ukukhiqizwa kwamangqamuzana glucocorticoids - cortisol, cortisone futhi adrenokortikosterona. La ma-hormone ngenkuthalo esetshenziswa umzimba ukuze sikhuthaze labo noma kwamanye amangqamuzana nezindlala. i-hormone isinyathelo indlela kusekelwe ngibopha kwabo receptor adrenergic ethize etholakala izicubu eziningi, futhi imithambo yegazi. Njengoba kushiwo ngenhla, la ma-hormone kukhona "ukucindezeleka", okungukuthi ukwandisa umsebenzi umzimba ebukhoneni ingozi ngenxa yimuphi lwegciwane.

La ma-hormone nomthelela asebenzayo eqeda ukuvuvukala, okwenza nemikhiqizo yabo zokwenziwa ziye zasetshenziswa imithi.

Ngaphezu kwalokho, phakathi ACTH futhi hormone adrenal unokuxhumeka ezithile: ikhemikhali kwandisa lokuhlushwa hormone adrenal futhi ngokweqile yabo kuholela yokuthi uyayeka ukukhiqiza ACTH (i-hormone). Kuyini for lomkhuba, futhi kungani lokhu okwenzekayo - Namanje akwaziwa, kodwa indida ngokwalo ubizwa ngokuthi "impendulo".

Ukubaluleka basemtholampilo

ACTH kuvusa umsebenzi adrenal. Ngaphandle kwale hormone, lezi nezindlala kungaba ngasebenzi, okwakuyoholela izifo ezihlukahlukene.

Nokho, ngezinye izikhathi kuyenzeka futhi ukuze inani ACTH egazini kuyahlukahluka, nenchazelo kuyadingeka. I-hormone ACTH, izinga zazo e Igazi liyakuba elilingana amayunithi kusuka 9 46 (pg / ml) likhombisa umsebenzi singokwemvelo futhi siyafaneleka nemisebenzi yokusetshenziswa pituitary. Inani le-hormone angase iyokhushulwa noma ukwehla (ngokuvamisile - ukuba ukuntuleka eliphelele egazini).

Ukuze sithole izinga peptide esetshenziswa ACTH test.

Ivame kwenziwe amacala khona esolwa isifo. Abaphilileyo kokuqhuba yalolu cwaningo ayiboniswa.

Ukwahlulela ngokubukeka ezingeni le-hormone in the lokuhlushwa igazi, baphetha ngokuthi, ngalokho seliyekiwe yinqubo sokugembula - ezingeni eksisi hypothalamic-pituitary ngenxa yanoma iyiphi uxhumano phakathi ezingeni nezindlala adrenal kanti indlala pituitary.

Ukunqunywa amazinga ama-hormone igazi

Njengoba sekushiwo, ukucacisa lokuhlushwa hormone ezidingekayo ACTH - test. Le nqubo ikuvumela ukunquma ukuthi le hormone egazini.

Ngobusuku obandulela cwaningo kunconywa ukuba bangakwenzi ukuzivocavoca, kanye uyeke utshwala kanye izinto psychotropic. Akunconyelwe ukudla oyingozi futhi ngabhema. 3 amahora ngaphambi kwesifundo asivunyelwe ukubhema.

Igazi ngokuvamile asebenzelana ngayo esiswini esingenalutho ekuseni (kuphela uma azikho imithetho endocrinology ekhethekile). Kwezinye izimo (ngoba esolwa isifo Cushing sika), i-hormone wafunda kusihlwa.

Ukuze ucwaninge igazi emithambo yegazi isiguli. Kuyinto kuwo kunqunywa hormone adrenocorticotropic.

ACTH (level yayo) emva Imiphumela iqhathaniswa inkomba amagugu (i-hormone evamile iqukethe kusuka 9 46 pg / ml). Noma yimuphi ukuphambuka ngokuvamile waqonda njengoba okungavamile.

Izizathu bandise izindlela ACTH

Yikuphi izifo anda ACTH? Lezi zinqubo sokugembula zihlanganisa:

  • isifo Addison sika (isifo lethusi, eyinhloko esingamahlalakhona adrenal). ACTH ezingeni liphuma ngenxa yokuthi kukhiqizwa ama-hormone ekhiqizwa yindlala okuthiwa adrenal.
  • Hyperplasia azalwa naso.
  • isifo Cushing sika (kwenyuke amanani le-hormone ngenxa lokuhlala zokucabanga okubangelwa isifo CRH).
  • Syndrome zokukhiqiza ACTH ethunjini (isifo ezihambisana ne ukuthuthukiswa pituitary izicubu obangela ukukhiqizwa ACTH indawo atypical).
  • Nelson Syndrome.
  • Paraneoplastic syndrome (isimila).
  • Imibandela ehambisana ne-ukuhlinzwa noma ukuhlukumezeka.
  • Virilism nezindlala adrenal.
  • Administration izidakamizwa ngqo (hormone ngqo pituitary) noma ngokungaqondile (by ezithinta le ngxenye nokucindezela nezindlala adrenal) lokulawula indlala pituitary.
  • ukucindezeleka okukhulu noma isimo kakhulu.

amazinga ama-hormone encishisiwe

Kungaphansi kwaziphi izimo ACTH eyehlisiwe?

  • Secondary esingamahlalakhona adrenal. ACTH ukwehla kwaba ngenxa yokuthi ukuthi hormone adrenal kuthiwa Nokho ithuthukiswe isamba esikhulu ngokweqile, ayikwazanga ukubonisa umsebenzi walo.
  • isimila adrenal (Cushing Syndrome). Lokhu kumiswa kwandisa izicubu-hormone okuthiwa i-producing, ngenxa kuholela amazinga anda adrenal hormone ACTH zamagama kanye okusithiyayo.
  • Ukusebenzisa kriptogeptadina. Lesi sidakamizwa kuhloswe abacindezela isikhungo indlala elise hypothalamus. Ngenxa yalokho, le kungenziwa ukuyiveza zamagama liberinov.
  • neoplasms Kortizolprodutsiruyuschie. Uhlukile isimila nge Cushing Syndrome, kodwa umphumela uyefana.
  • Ukusetshenziswa glucocorticoid izidakamizwa ebulilini. indlela Usilika kunciphisa ukukhiqizwa yemvelo hormone adrenal, kodwa ngenxa lokuhlala enkulu okokufaka eyeka esikhiqiza ACTH.

Ukwelashwa kweziguli amazinga ama-hormone okushintshiwe

ukwelapha njani isiguli uma liye landa i-hormone adrenocorticotropic?

ACTH (hormone) zingalawulwa by yokwelapha izidakamizwa, ukuchayeka kanye nokusebenzisa izindlela kuhlinzwa.

yokwelapha Medical kuhlanganisa nokusetshenziswa cytostatics (uma sisetshenziswe njengesigungu sokufaka ukwanda kanye nokuncipha kwama-hormone). Ngokuvamile, basuke asetshenziswa eqinisekisa khona umdlavuza. Inqubo esetshenziswa kabanzi "Hloditan", "Mercaptopurine".

ukwelashwa ngemisebe isetshenziselwa indawo isimila kumiswa endaweni zobuchopho. Sebenzisa gamma-therapy noma i-proton umthelela.

kokungenela Steel inikezwa uma kwenzeka ukwehluleka ukwelashwa ngoludala (izidakamizwa ngemisebe). indlala adrenal ngokuvamile isuswe, kulandele yelashwa ngamakhemikhali. Brain izimila ziphinde zisuswe Nokho, uzongenela ngempela eziyinkimbinkimbi, ngakho-ke Kwenziwa njalo.

Izinkinga ezihambisana nezinguquko sama-hormone asemzimbeni

Kaningi kuyenzeka ukuthi i ezingeni anda noma kwehle of ACTH kungaholela yezinkinga ezihlukahlukene.

Inkinga adrenal - isimo ezivamile eholela yokuthi kukhuphuke ACTH (hormone). Kuyini lokhu?

Inkinga adrenal libhekene nenkinga yezinga ngokungavamile okusezingeni eliphezulu hormone adrenal ububonisa tachycardia, yokucindezeleka okwandayo. Ngenxa yalokhu, ngokuvamile ukuthuthukisa ukumelwa inhliziyo nokushaywa unhlangothi. Ngaphezu kwalokho, isimo esibucayi kungaholela Ukuwohloka umzimba, okuyinto iyingozi kakhulu futhi kungaholela ekufeni.

Ukwehlisa ezingeni ACTH ngokuvamile kuholela ukuthuthukiswa esingamahlalakhona adrenal, izikhathi zokudakwa njalo yokufikelwa noma nciphisa. Ngaphezu kwalokho, ingxenye ephukile umsebenzi zocansi (njengaku nezindlala adrenal ukukhiqiza nengcosana testosterone futhi estrogen).

Impela ukuze kuvinjelwe ukuthuthukiswa yalezi zinkinga, kunconywa ngendlela esifike ngesikhathi ukulawula izinga lama-hormone.

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