Proton-futha inhibitor: mshini wezenzo kanye nesicelo ku imithi

Ngu-proton futha inhibitor yiqoqo ejenti kwemithi ukuthi sinciphise izinga lokutholakala kwengculazi uketshezi of hydrochloric acid esiswini. Ukuba nomthelela ngqo kwi canaliculi secretory, bona ngempumelelo eziholela oyifunayo zokwelapha umphumela izilonda, kolwelwesi erosive, Gerd. Iqembu kuhlanganisa sebuningini izidakamizwa ezifanayo chemical isakhiwo, kodwa kokuba nemingcele ezahlukene pharmacodynamic, isb cishe imithi efanayo isinyathelo amaseli secretory, kodwa ukwenze lokuhlala ehlukene kanye aphenduka ngejubane elingafani.

Proton futha inhibitor: izici yamangqamuzana ithonya amalungiselelo

Proton futha kuyinto eziyinkimbinkimbi amaprotheni isakhiwo ebusayo Ukungena hydrogen ion in the Isikhala sayo esingaphakathi esiswini. It inezigaba ezimbili ezihluke amakhemikhali, ngokuthi ngenye subunits. Esokuqala siku-protein ne-yakhiwe kusukela ama-amino acid. Ngo ulwelwesi cell stuffer ukuthi iziphatha ngendlela ekhethekile, waliwela izikhathi 10, okuholela kwetinhlavu izihibe isiteshi 5-secretory. Kudlulwa ngalo ingaphakathi ion kuwela ngaphakathi inesikhala esiswini kanye ukunikeza acidification medium eziphonsa hydrogen Inkomba. Kulokhu kuba kwelinye izihibe liyisikhungo asebenzayo amaprotheni - ekulandelaneni 800 amino acid, okuyinto catalyzes ukubhidlika ATP, main amandla iseli substrate.

Okunye subunit kuyinto eziyinkimbinkimbi iprotheni yakhiwa ukulandelana polypeptide, ngokulandelana othile ngaphambilini isakhiwo kanye glycoprotein ngamaketanga. Ingxenye obuqand engqamuzaneni lingaphandle cytoplasm, futhi ingxenye glycoprotein cishe kuyinto ekstratsitoplazmaticheskim yokwamukela eziyinkimbinkimbi ukuthi ucosha isignali ye ukusebenza enzyme H + \ K + -ATPase. Kulokhu ingxenye amaprotheni engqamuzaneni kweqa ulwelwesi kanye, esikisela ukuthi inani lalo lizoba njengoba isici yokuxhuma phakathi yangaphandle futhi owokuqala yokwamukela subunit obhekene izifundo ukusabela okhanda amanye amathuba synthesis proton.

Ngakho, ukwakheka proton futha tubules secretory amaseli parietal singaphetha kanjani ngendlela elula ungakwazi ukuvimbela uketshezi of H + engena ingaphakathi lomzimba. Samuntu kulingane kakhulu - kuyinto okusithiyayo of enzyme obangela zamagama ezenza proton futha inhibitor.

Ukusetshenziswa inhibitor e umkhuba emtholampilo

Kwezokwelapha, i-proton futha inhibitor asetshenziswa kabanzi, ikakhulukazi Gastroenterology, okuyinto ezihlobene ikhono lazo ukunciphisa asidi we esiswini uketshezi, ngaleyo ndlela unciphise ukushuba zilimaze odongeni esiswini, okuyinto ebaluleke kakhulu kangakanani uma abavusa. Kulokhu umphumela zokwelapha kuzimele etiology we ukuvuvukala, njengoba isuswa ithonya nolaka imvelo kwi bomzimba. Futhi nomkhakha we pathologies okuyinto ukwelashwa ukuze isetshenziswe ngempumelelo proton futha inhibitor inwetshelwe ngu isilonda esiswini kanye isilonda duodenal, erosive futhi Gerd-non-erosive amafomu.

Phakathi imithi ezivame kakhulu zihlanganisa i-proton futha inhibitor nge amagama alandelayo ejwayelekile omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, nabanye. Phakathi kwabo kukhona amagama akho okuhweba ivelele, njengokuthi "Omez". Imithi ayatholakala ifomu capsule. Ezithathwe ngomlomo umthamo enqunyiwe onguchwepheshe, okuyinto iyahlukahluka kuye ngokuthi uhlobo oluthile isifo. Nakuba sivumele self-nokuphathwa, njengoba kukhona iqembu ekubulaleni iziguli ezigulela esekhala exacerbation ezithile zonyaka izilonda esiswini noma duodenal ezingamahlalakhona. Kwezinye izimo, ukwamukela luboniswana udokotela ngesikhathi ukulaliswa esibhedlela.